The Hippo-YAP/TAZ signaling pathway plays a critical role in tissue homeostasis, tumorigenesis, and degeneration disorders.The regulation of YAP/TAZ levels is controlled by a complex regulatory network, where several feedback loops have been identified.However, it remains elusive how these feedback loops contain the YAP/TAZ levels and maintain the
Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels.Hepcidin expression is regulated by the BMP6/SMAD and IL6/STAT signaling cascades.Deregulation of either pathway causes iron-related diseases such as hemochromatosis or anemia of
The aim of this study was determined that arterial vascularization VITD3 400 IU LIQULD of testicles, epididymis and ductus de-fereces in Chinchilla.Five adult male chinchilla (Chinchilla lanigera) varied between 550 g and 600 g live body weight obtained from Afyon Kocatepe University Experimental Animal Unit were used in the study.Blood was removed
Supermassive black holes (SMBH), found at the centers of galaxies, have been observed in the early Universe, yet their rapid growth remains an open question.When SMBHs form binary systems during galaxy mergers, they are expected to emit strong gravitational waves (GW).A large population of such binaries would produce a stochastic gravitational wave